What is the recommended dose of Apixaban for individuals with risk factors for bleeding?

The recommended dose of Apixaban for individuals with risk factors for bleeding is 2.5 mg daily. This lower dose is advised primarily for patients who may be more susceptible to bleeding due to various medical conditions or age factors, such as those over 80 years old, or those with renal impairment or low body weight. The use of a reduced dose helps to balance the benefits of anticoagulation against the risk of serious bleeding complications.

Using the lower dose of 2.5 mg daily preserves the effectiveness of the drug while minimizing potential adverse effects that could arise in at-risk populations. This approach is critical in clinical settings where the safety of the patient is of utmost importance.

In contrast, higher doses like 5 mg daily or 10 mg daily may be appropriate for patients without significant risk factors but could be too hazardous for those with bleeding risks. The 1 mg daily option is not within the recommended dosing range for Apixaban as it does not provide adequate anticoagulation for clinical indications. Therefore, 2.5 mg daily represents the most appropriate dosing strategy for individuals with increased risks for bleeding.