Which class of antihyperglycaemics includes drugs known as 'Gli-'?

The class of antihyperglycaemics that includes drugs known as 'Gli-' is the sulfonylureas. Sulfonylureas work by stimulating the pancreas to release more insulin in response to glucose, thereby helping to lower blood sugar levels in individuals with type 2 diabetes. Examples of these medications include glipizide, glibenclamide, and glyburide, all of which begin with the prefix 'Gli-'.

Each of the other classes of antihyperglycaemics has distinct mechanisms of action and drug names that do not feature the 'Gli-' prefix. For instance, GLP-1 receptor agonists, such as liraglutide and semaglutide, work by enhancing glucose-dependent insulin secretion and suppressing glucagon secretion. SGLT2 inhibitors, like canagliflozin and empagliflozin, function by preventing glucose reabsorption in the kidneys, leading to increased glucose excretion. DPP-4 inhibitors, such as sitagliptin and saxagliptin, work by inhibiting the enzyme that breaks down incretin hormones, which help to regulate insulin and blood sugar levels.

Thus, sulfonylureas are specifically noted for their 'Gli-'