Which NSAID is associated with the lowest cardiovascular risk?

Naproxen is recognized for having a relatively lower cardiovascular risk compared to other nonsteroidal anti-inflammatory drugs (NSAIDs). Studies have indicated that while all NSAIDs have potential cardiovascular risks, naproxen tends to have a protective effect on the cardiovascular system, making it a safer option in patients who may have existing heart conditions or are at risk of cardiovascular events.

In contrast, other NSAIDs like diclofenac and celecoxib have been associated with an increased risk of heart attack and stroke. Ibuprofen, while commonly used and generally with a more favorable safety profile, has been noted to carry a moderate risk similar to that of other non-selective NSAIDs but does not offer the same potential cardiovascular protection that naproxen does.

Therefore, considering the available evidence and safety profiles, naproxen stands out as the NSAID associated with the lowest cardiovascular risk, making it a preferred option in certain patient populations who require anti-inflammatory treatment but have cardiovascular concerns.